There are 4 main attributes that set Biodesign apart.
Biodesign communicates with the body, signaling surrounding tissue to grow across the scaffold, allowing the body to restore itself.
Growth Factors and Proteins Key to Signaling
The processing of Biodesign carefully maintains inherent growth factors and glycoproteins that give it the unique ability to signal the body to restore itself. Many other biologic grafts are processed in a way that removes noncollagen elements, limiting the graft's signaling ability.
Once Biodesign is implanted in the body, growth factors and proteins augment the body's natural response to begin healing. When new cells begin to infiltrate the scaffold, signaling factors such as glycosaminoglycans and glycoproteins help guide the cells toward remodeling.
Active Elements
|
Biodesign |
Other Biologics |
| Collagen |
I,III,IV,VI |
√ |
| Growth factors |
√ |
|
Glycosaminoglycans
(heparin, chondroitins,
hyaluronic acid) |
√ |
|
Glycoproteins
(fibronectin, laminin) |
√ |
|
| Proteoglycans |
√ |
|
| Elastin |
Trace |
√ |
Data on file at Cook Biotech, Inc., West Lafayette, IN
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Moderate Cost
Biodesign is priced moderately compared to the high cost of other biologic grafts, and is often priced comparably to synthetic mesh.
Widespread Availability
Biodesign is widely available and is terminally sterilized.
Variety of Shapes and Sizes
Biodesign is available in a variety of shapes and sizes designed specifically to fit the patient's anatomy for common tissue repairs. It's also available in flat sheets that can be cut to a shape and size for a specific procedure.
Ready to Use
Biodesign can be stored at room temperature and has shelf life of 18 months. It requires minimal preparation, with a short rehydration time.
»Show References
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Nihsen ES, Johnson CE, Hiles MC.
Bioactivity of small intestinal submucosa and oxidized regenerated cellulose/collagen.
Adv Skin Wound Care. 2008;21(10):479-486.
Hodde J, Janis A, Ernst D, et al.
Effects of sterilization on an extracellular matrix scaffold: part I. Composition and matrix architecture.
J Mater Sci Mater Med. 2007;18(4):537-543.
Hodde J, Janis A, Hiles M.
Effects of sterilization on an extracellular matrix scaffold: part II. Bioactivity and matrix interaction.
J Mater Sci Mater Med. 2007;18(4):545-550.
Niezgoda JA, Van Gils CC, Frykberg RG, et al.
Randomized clinical trial comparing OASIS Wound Matrix to Regranex Gel for diabetic ulcers.
Adv Skin Wound Care. 2005;18(5, pt 1):258-266.
Hodde JP, Ernst DM, Hiles MC.
An investigation of the long-term bioactivity of endogenous growth factor in OASIS Wound Matrix.
J Wound Care. 2005;14(1):23-25.
Badylak SF, Park K, Peppas N, et al.
Marrow-derived cells populate scaffolds composed of xenogeneic extracellular matrix.
Exp Hematol. 2001;29(11):1310-1318.
Biodesign remodels into fully vascularized tissue, allowing the body's own defense mechanisms to reach and respond to infection. This ability to remodel provides the basis for infection resistance.
Five year data supports the use of Biodesign for hernia repair in contaminated or potentially contaminated fields. Additionally, a recently published meta-analysis shows that use in clean fields offers even more success.
Download a procedural guide to achieving best outcomes in hernia repair (PDF).
»Show Additional Benefits
»Hide Additional Benefits
Moderate Cost
Biodesign is priced moderately compared to the high cost of other biologic grafts, and is often priced comparably to synthetic mesh.
Widespread Availability
Biodesign is widely available and is terminally sterilized.
Variety of Shapes and Sizes
Biodesign is available in a variety of shapes and sizes designed specifically to fit the patient's anatomy for common tissue repairs. It's also available in flat sheets that can be cut to a shape and size for a specific procedure.
Ready to Use
Biodesign can be stored at room temperature and has shelf life of 18 months. It requires minimal preparation, with a short rehydration time.
»Show References
»Hide References
Franklin ME Jr, Treviño JM, Portillo G, et al.
The use of porcine small intestinal submucosa as a prosthetic material for laparoscopic hernia repair in infected and potentially contaminated fields: long-term follow-up.
Surg Endosc. 2008;22(9):1941-1946.
Champagne BJ, O'Connor LM, Ferguson M, et al.
Efficacy of anal fistula plug in closure of cryptoglandular fistulas: long-term follow-up.
Dis Colon Rectum. 2006;49(12):1817-1821.
Shell DH 4th, Croce MA, Cagiannos C, et al.
Comparison of small-intestinal submucosa and expanded polytetrafluoroethylene as a vascular conduit in the presence of gram-positive contamination.
Ann Surg. 2005;241(6):995-1004.
Sarikaya A, Record R, Wu CC, et al.
Antimicrobial activity associated with extracellular matrices.
Tissue Eng. 2002;8(1):63-71.
Badylak SF, Coffey AC, Lantz GC, et al.
Comparison of the resistance to infection of intestinal submucosa arterial autografts versus polytetrafluoroethylene arterial prostheses in a dog model.
J Vasc Surg. 1994;19(3):465-472.
Biodesign completely remodels into strong, fully vascularized tissue. Once the healing process is complete, Biodesign is undetectable—providing a permanent repair without a permanent material.
(Please note the following images are graphic in nature and may be disturbing to some patients.)
View the progression of remodeling in these images. Initial placement of the graft is shown first, and in the next three images, the graft is gradually replaced by vascularized tissue.
»Show Additional Benefits
»Hide Additional Benefits
Moderate Cost
Biodesign is priced moderately compared to the high cost of other biologic grafts, and is often priced comparably to synthetic mesh.
Widespread Availability
Biodesign is widely available and is terminally sterilized.
Variety of Shapes and Sizes
Biodesign is available in a variety of shapes and sizes designed specifically to fit the patient's anatomy for common tissue repairs. It's also available in flat sheets that can be cut to a shape and size for a specific procedure.
Ready to Use
Biodesign can be stored at room temperature and has shelf life of 18 months. It requires minimal preparation, with a short rehydration time.
»Show References
»Hide References
Woo SL, Takakura Y, Liang R, et al.
Treatment with bioscaffold enhances the fibril morphology and the collagen composition of healing medial collateral ligament in rabbits.
Tissue Eng. 2006;12(1):159-166.
Desai KM, Diaz S, Dorward IG, et al.
Histologic results 1 year after bioprosthetic repair of paraesophageal hernia in a canine model.
Surg Endosc. 2006;20(11):1693-1697.
Oelschlager BK, Pellegrini CA, Hunter J, et al.
Biologic prosthesis reduces recurrence after laparoscopic paraesophageal hernia repair: a multicenter, prospective, randomized trial.
Ann Surg. 2006;244(4):481-490.
Smith MD, Campbell RM.
Use of a biodegradable patch for reconstruction of large thoracic cage defects in growing children.
J Pediatr Surg. 2006;41(1):46-49.
Wiedemann A, Otto M.
Small intestinal submucosa for pubourethral sling suspension for the treatment of stress incontinence: first histopathological results in humans.
J Urol. 2004;172(1):215-218.
Over time, Biodesign remodels to become as strong as the patient's own tissue. Dermis-based biologic grafts leave behind elastin, which can cause stretching over time. Synthetic mesh and chemically cross-linked biologic grafts can lead to scarring, erosion and encapsulation.
This graph illustrates how Biodesign repair maintains strength throughout the natural remodeling process. In fact, a repair made with Biodesign gets stronger over time and becomes stronger than the normal body wall.Fewer Recurrences Than Competing Products
A recently published systematic review shows that failure rates for dermis-based biologic grafts used in hernia repair are as high as 14% at 12-14 month follow-up. At 19 month follow-up, hernia recurrence rates with Biodesign are only 6.7%.
»Show Additional Benefits
»Hide Additional Benefits
Moderate Cost
Biodesign is priced moderately compared to the high cost of other biologic grafts, and is often priced comparably to synthetic mesh.
Widespread Availability
Biodesign is widely available and is terminally sterilized.
Variety of Shapes and Sizes
Biodesign is available in a variety of shapes and sizes designed specifically to fit the patient's anatomy for common tissue repairs. It's also available in flat sheets that can be cut to a shape and size for a specific procedure.
Ready to Use
Biodesign can be stored at room temperature and has shelf life of 18 months. It requires minimal preparation, with a short rehydration time.
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